GDC-2992
GDC-2992 is an orally bioavailable, selective androgen receptor (AR) degrader with a DC50 of 2.7 nM. It demonstrates potent anti-proliferative activity (IC50 = 9.7 nM in VCaP cells) and is a valuable research tool for investigating castration-resistant prostate cancer (CRPC) in both cellular and animal models.
Product Specifications
CAS Number
2753651-10-2
Product Name Alternative
RO7656594, RO 7656594, GDC2992
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
99.82% (May vary between batches)
Solubility
DMSO:30 mg/mL (36.61 mM)
Smiles
O ([C@H]1C (C) (C) [C@H] (NC (=O) C2=CC=C (C=C2) N3CCC (CN4CCN (CC4) C=5C=C6C (=CC5) C (=O) N (N=C6) [C@@H]7C (=O) NC (=O) CC7) CC3) C1 (C) C) C8=CC (Cl) =C (C#N) C=C8
Molecular Formula
C45H51ClN8O5
Molecular Weight
819.39
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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