GSK4418959
GSK4418959 (IDE275) is an orally bioavailable, selective, and reversible ATP-competitive inhibitor of Werner syndrome helicase (WRN) . It potently blocks WRN's ATPase and helicase activities, serving as a key research tool for investigating WRN's essential role in MSI-H cancer models, both in cellular and in vivo studies.
Product Specifications
CAS Number
3064599-36-3
Product Name Alternative
IDE 275, IDE275, GSK 4418959
Field of Research
Cell Biology, Molecular Biology
Purity
99.14% (May vary between batches)
Solubility
DMSO:80 mg/mL (123.71 mM)
Smiles
C (O) (=O) [C@@H]1[C@H] (CCC[C@H]1C (NC2=C (F) C=C (C (F) (F) F) C=C2) =O) C3=CC=C (N (S (=O) (=O) C=4C=C5C (=CC4) N (C) C (C) =N5) C) C=C3
Molecular Formula
C31H30F4N4O5S
Molecular Weight
646.65
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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