BMS-986449
BMS-986449 is a molecular glue CELMoD that induces the Cereblon-mediated degradation of IKZF2 (Helios) and IKZF4 (Eos) . This targeted degradation in regulatory T cells (Tregs) is being investigated in preclinical research for its potential to enhance anti-tumor immunity in cancer immunotherapy models.
Product Specifications
CAS Number
2850300-72-8
Product Name Alternative
BMS986449, BMS 986449
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
98.18% (May vary between batches)
Smiles
CC1=C (C) C (N) =NC (C2=C (F) C ([C@@H] (C) N ([C@H]3CCC (NC3=O) =O) C4=O) =C4C=C2) =C1
Molecular Formula
C21H21FN4O3
Molecular Weight
396.42
Storage Conditions
-20°C
Notes
For research use only.
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