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BMS-986449

BMS-986449 is a molecular glue CELMoD that induces the Cereblon-mediated degradation of IKZF2 (Helios) and IKZF4 (Eos) . This targeted degradation in regulatory T cells (Tregs) is being investigated in preclinical research for its potential to enhance anti-tumor immunity in cancer immunotherapy models.

Product Specifications

CAS Number

2850300-72-8

Product Name Alternative

BMS986449, BMS 986449

Field of Research

Immunology & Inflammation, Pharmacology & Drug Discovery

Purity

98.18% (May vary between batches)

Smiles

CC1=C (C) C (N) =NC (C2=C (F) C ([C@@H] (C) N ([C@H]3CCC (NC3=O) =O) C4=O) =C4C=C2) =C1

Molecular Formula

C21H21FN4O3

Molecular Weight

396.42

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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