Polθ-IN-7
Polθ-IN-7 (example 12) is a potent and selective small-molecule inhibitor of DNA polymerase theta (Polθ), exhibiting a Ki value of 1.27 nM. This inhibitor is a valuable research tool for studying DNA repair mechanisms, particularly in the context of targeting homologous recombination-deficient cancers in both cellular and biochemical assays.
Product Specifications
CAS Number
2923356-52-7
Field of Research
Cell Biology, Infectious Disease & Virology, Molecular Biology
Smiles
O=C1[C@]2 (N (C (=O) C[C@@]2 (CN (CCN3CCN (C) CC3) C=4C (N1C) =CC=CC4C) [H]) C5=CC (C (F) (F) F) =CC (C) =N5) [H]
Molecular Formula
C28H35F3N6O2
Molecular Weight
544.612
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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