Aurora-A ligand 1
Aurora-A ligand 1 is a potent, selective Aurora-A inhibitor (Kd = 0.85 nM) used as a target-binding moiety in PROTAC degraders. It serves as a key intermediate in synthesizing compounds like HLB-0532259, which demonstrate antitumor activity in neuroblastoma models in vitro and in vivo.
Product Specifications
CAS Number
2541626-73-5
Field of Research
Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C (O) C1=CC=C (C=C1) NC=2N=CC=3C=C (C (=O) N (C) C) N (C3N2) C4CCCC4
Molecular Formula
C21H23N5O3
Molecular Weight
393.439
Storage Conditions
-20°C
Notes
For research use only.
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