NLRP3-IN-60
NLRP3-IN-60 (Compound 39) is a potent, orally active NLRP3 inflammasome inhibitor. It blocks pyroptosis in THP-1 cells (IC50 = 13 nM) and inhibits IL-1β secretion in human whole blood (IC50 = 225 nM), supporting its use in researching inflammatory diseases in both cellular and systemic models.
Product Specifications
CAS Number
3098827-88-1
Field of Research
Cell Biology, Immunology & Inflammation
Smiles
CC (C) C1=C (C=CC2=C1CC (=O) NS (=O) (=O) C3=CN (C (COC4=NC=CC2=C4) (C) C) N=C3F) F
Molecular Formula
C23H24F2N4O4S
Molecular Weight
490.523
Storage Conditions
-20°C
Notes
For research use only.
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