NLRP3-IN-60
NLRP3-IN-60 (Compound 39) is a potent, orally active NLRP3 inflammasome inhibitor. It blocks pyroptosis in THP-1 cells (IC50 = 13 nM) and inhibits IL-1β secretion in human whole blood (IC50 = 225 nM), supporting its use in researching inflammatory diseases in both cellular and systemic models.
Product Specifications
CAS Number
3098827-88-1
Field of Research
Cell Biology, Immunology & Inflammation
Smiles
CC (C) C1=C (C=CC2=C1CC (=O) NS (=O) (=O) C3=CN (C (COC4=NC=CC2=C4) (C) C) N=C3F) F
Molecular Formula
C23H24F2N4O4S
Molecular Weight
490.523
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K1709002 1.0 µg DNA
PPP3CA sgRNA CRISPR Lentivector (Human) (Target 1)
Sign In for Pricing
View Details 
MR225021L3V 200 µL
Wiz (NM_011717) Mouse Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details 
orb1661687 96 Tests
Human BTLA/B- and T-lymphocyte attenuator ELISA Kit
Sign In for Pricing
View Details