Pan-Raf/RTK inhibitor 1
Compound I-16 is a potent pan-Raf inhibitor with low nanomolar IC50 values against BRafV600E, ARaf, BRafWT, and CRaf. It demonstrates antiproliferative effects in cancer cell lines and is a valuable tool for investigating Raf-driven signaling in both in vitro and in vivo cancer research models.
Product Specifications
CAS Number
1980821-53-1
Field of Research
Neuroscience; Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C (NC1=CC=C (C (=C1) C (F) (F) F) CN2CCOCC2) C3=CC=C (C (=C3) NC (=O) C4 (C5=NC=NC=6N=CNC65) CC4) C
Molecular Formula
C29H28F3N7O3
Molecular Weight
579.573
Storage Conditions
-20°C
Notes
For research use only.
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