(R) -LW-Srci-8
(R) -LW-Srci-8 is a selective covalent inhibitor of c-Src (IC50= 35.83 nM) that disrupts the autophosphorylation of c-Src by targeting its autophosphorylation site (Y419) [1].
Product Specifications
UNSPSC
12352005
Target
Src
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-lw-srci-8.html
Solubility
10 mM in DMSO
Smiles
FC1=CC([C@@H](N(C2CC2)C(C=C)=O)C(NC3CCCC3)=O)=CC(F)=C1
Molecular Formula
C19H22F2N2O2
Molecular Weight
348.39
References & Citations
[1]Zhang H, et al. Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c-Src Kinase. ACS Chem Biol. 2024;19 (4) :999-1010.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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