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JB300

JB300 is a potent and selective PROTAC degrader of Aurora A kinase (DC50 = 30 nM), composed of the MK-5108 ligand, a PEG2 linker, and a Thalidomide-based E3 ligase recruiter. It is a valuable chemical tool for probing Aurora A biology and exploring targeted protein degradation strategies in cancer research, applicable in both cellular and in vivo models.

Product Specifications

CAS Number

3038446-90-8

Field of Research

Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery

Smiles

C ([C@@]1 (C (NCCOCCOCCNC (COC2=C3C (C (=O) N (C3=O) C4C (=O) NC (=O) CC4) =CC=C2) =O) =O) CC[C@@H] (OC5=C (F) C (Cl) =CC=C5) CC1) C=6N=C (NC7=NC=CS7) C=CC6

Molecular Formula

C43H45ClFN7O10S

Molecular Weight

906.375

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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