EGFR-IN-142
EGFR-IN-142 (compound 9a) is a potent small molecule EGFR inhibitor with an IC50 of 0.08 μM. It demonstrates selective antiproliferative activity in vitro, showing greater potency against MCF-7 breast cancer cells (IC50 = 3.31 μM) than against non-cancerous WI-38 fibroblasts (IC50 = 43.99 μM) . This compound is a useful research tool for studying EGFR-driven cancers in cellular models.
Product Specifications
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
C1=CC=C (C=C1) CSC2=NN=C (S2) NC (=O) CSC3=NN=C (S3) SCC (=O) NC4=NN=C (S4) SCC5=CC=CC=C5
Molecular Formula
C24H20N8O2S7
Molecular Weight
676.923
Storage Conditions
-20°C
Notes
For research use only.
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