P-Aminophenylmercuric acetate

P-Aminophenylmercuric acetate is an organomercurial activator of matrix metalloproteinases (MMP) . P-Aminophenylmercuric acetate participates in the activation and inhibition of MMP-8 by attacking protein sulfhydryl or inducing cysteine switching reaction. p-Aminophenylmercuric acetate promotes the shedding of betacellulin precursor (pro-BTC) . p-Aminophenylmercuric acetate influences the binding of agonists and antagonists to the opiate receptor[1][2][3].

Product Specifications

CAS Number

[6283-24-5]

UNSPSC

12352200

Hazard Statement

H301

Target

Cathepsin; MMP

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/p-aminophenylmercuric-acetate.html

Purity

99.07

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C)O[Hg]C1=CC=C(C=C1)N

Molecular Formula

C8H9HgNO2

Molecular Weight

351.75

Precautions

H301

References & Citations

[1]Sanderson M P, et al. ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx[J]. Journal of Biological Chemistry, 2005, 280 (3) : 1826-1837.|[2]PASTERNAK G W, et al. Differential effects of protein-modifying reagents on receptor binding of opiate agonists and antagonists[J]. Molecular Pharmacology, 1975, 11 (3) : 340-351.|[3]Gendron R, et al. Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidine[J]. Clinical Diagnostic Laboratory Immunology, 1999, 6 (3) : 437-439.