PROTAC SMARCA2/4 degrader-36
PROTACSMARCA2/4 degrader-36 (Compound 29) is a highly potent, dual SMARCA2 and SMARCA4 degrader with DC50 values of 0.22 nM and 0.85 nM, respectively. It demonstrates robust antiproliferative activity in cellular assays, making it a valuable chemical probe for oncology research targeting SWI/SNF chromatin remodeling complexes.
Product Specifications
CAS Number
3033588-00-7
Field of Research
Epigenetics & Chromatin, Neuroscience, Pharmacology & Drug Discovery
Smiles
CC1 (C) C=2N (C=3C1=CC (=CC3) C4CCN (C[C@H]5CC[C@@H] (CC5) C6=CN ([C@H] (C (=O) N7[C@H] (C (N[C@@H] (C) C8=CC=C (C=C8) C9=C (C) N=CS9) =O) C[C@@H] (O) C7) C (C) C) N=N6) CC4) C=%10C (C (=O) N2) =C (Cl) C=CC%10
Molecular Formula
C53H62ClN9O4S
Molecular Weight
956.635
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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