AV457
AV457 is a potent and selective mTOR inhibitor that effectively suppresses cyst growth in polycystic kidney disease (PKD) organoid models. It reduces phosphorylation of S6 and p70S6K without affecting P-AKT levels, making it a useful tool for studying mTORC1 signaling in PKD and cancer research.
Product Specifications
CAS Number
2713387-11-0
Field of Research
Signal Transduction
Smiles
C[C@@H]1CC[C@H]2C[C@@H] (/C (=C/C=C/C=C/[C@H] (C[C@H] (C (=O) [C@@H] ([C@@H] (/C (=C/[C@H] (C (=O) C[C@H] (OC (=O) [C@@H]3CCCCN3C (=O) C (=O) [C@@]1 (O2) O) [C@H] (C) C[C@@H]4CC[C@H] ([C@@H] (C4) OC) O) C) /C) O) OC) C) C) /C) NS (=O) (=O) CCOCCOC
Molecular Formula
C55H88N2O16S
Molecular Weight
1065.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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