PROTAC AR Degrader-8
PROTAC AR Degrader-8 (NP18) is a bifunctional degrader that potently targets both full-length and AR-V7 splice variant androgen receptors, inducing degradation, cell cycle arrest, and apoptosis in prostate cancer models like 22Rv1 and LNCaP cells, with demonstrated in vivo anticancer activity.
Product Specifications
CAS Number
3044108-04-2
Field of Research
Cell Biology, Metabolism Research, Pharmacology & Drug Discovery
Smiles
O=C1C=2C=CC=C (NCCOC3=CC=C (C=C3) C (C4=CC=C (OCC5=NC (=CC=C5) N6CCOCC6) C=C4) (C) C) C2C (=O) N1C7C (=O) NC (=O) CC7
Molecular Formula
C40H41N5O7
Molecular Weight
703.783
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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