AB3067
AB3067 is a heterobifunctional PROTAC degrader that simultaneously recruits the VHL and CRBN E3 ligases to potently degrade BET proteins (BRD2/3/4) . It demonstrates potent degradation and anti-proliferative activity in cellular models, making it a valuable chemical probe for studying BET biology and targeted protein degradation in cancer research.
Product Specifications
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
CC1=C (SC2=C1C (=N[C@H] (C3=NN=C (N32) C) CC (=O) OCCOCCOCCOCC (C) (COCCOCCOCCNC4=C (C=C5C (=C4) C (=O) N (C5=O) C6CCC (=O) NC6=O) F) COCC (=O) N[C@H] (C (=O) N7C[C@@H] (C[C@H]7C (=O) N[C@@H] (C) C8=CC=C (C=C8) C9=C (N=CS9) C) O) C (C) (C) C) C1=CC=C (C=C1) Cl) C
Molecular Formula
C74H91ClFN11O17S2
Molecular Weight
1525.16
Storage Conditions
-20°C
Notes
For research use only.
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