Mutant IDH1-IN-3
Mutant IDH1-IN-3 (Compound 1) is a potent and selective allosteric inhibitor of the R132H IDH1 mutant (IC50 = 13 nM) . It effectively reduces oncogenic D-2-hydroxyglutarate (2HG) production in cellular assays and is a valuable tool for investigating IDH1-mutant cancers in both in vitro and in vivo research contexts.
Product Specifications
CAS Number
1648909-73-2
Field of Research
Metabolism Research
Smiles
OC=1C (=CC (=CC1CN2C=NC=C2) C (C) (C) CC (C) (C) C) CN3C=NC=C3
Molecular Formula
C22H30N4O
Molecular Weight
366.5
Storage Conditions
-20°C
Notes
For research use only.
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