PROTAC LZK-IN-1
PROTAC LZK-IN-1 (Compound 21A) is a degrader of leucine zipper kinase (LZK/MAP3K13) . At 10 μM, it reduces LZK levels, downregulates p53 and c-Myc expression, and decreases viability in head and neck squamous cell carcinoma (HNSCC) cell lines, supporting its use in oncology research for in vitro mechanistic studies.
Product Specifications
CAS Number
2763268-64-8
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
C ([C@@H] (NC (CCCCCCC (=O) N1CCC (CC1) C=2C=C (N=C (NC3=CC (C#N) =CC=N3) C2) N4CCC (F) (F) C4) =O) C (C) (C) C) (=O) N5[C@H] (C (N[C@@H] (C) C6=CC=C (C=C6) C7=C (C) N=CS7) =O) C[C@@H] (O) C5
Molecular Formula
C51H64F2N10O5S
Molecular Weight
967.18
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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