P53 Activator 14
P53 Activator 14 (Compound 7A), a neratinib derivative, is a cell-permeable small molecule that induces DNA damage, activates p53, and inhibits cancer cell proliferation (IC50=7.21 μM in HCT116) . It demonstrates anti-metastatic, pro-apoptotic, and anti-angiogenic activity in both cellular assays and the chick CAM model, supporting its use in oncology research.
Product Specifications
CAS Number
2922588-44-9
Field of Research
Cancer Biology, Cell Biology
Smiles
O=C (NC1=CC=C (OCC2=NC=CC=C2) C (Cl) =C1) C3=CC=C (C=C3) CN4CCN (C (=O) C5CC5) CC4
Molecular Formula
C28H29ClN4O3
Molecular Weight
505.008
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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