AZ14240475
AZ14240475 is a brain-penetrant, selective small molecule inhibitor targeting EGFR exon 20 insertion mutants, exhibiting a pIC50 of 7.6. It is a valuable research tool for investigating this oncogenic driver in both cellular assays and in vivo preclinical models of non-small cell lung cancer.
Product Specifications
CAS Number
3101563-06-5
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
C=CC (=O) N1CC2=C (C1) N (C (=N2) C3=CC (=C (C=C3F) F) OC4=NC=CC (=C4) Cl) C5=NC=NC=C5
Molecular Formula
C23H15ClF2N6O2
Molecular Weight
480.854
Storage Conditions
-20°C
Notes
For research use only.
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