RIPK1-IN-28
RIPK1-IN-28 (compound 13) is a potent, orally bioavailable RIPK1 inhibitor, demonstrating sub-nanomolar IC50 values of 0.4 nM and 1.2 nM in human I2.1 and Hepa1-6 cells, respectively. This small molecule is a valuable research tool for investigating RIPK1-mediated pathways in necroptosis and inflammation, applicable in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
2968509-28-4
Field of Research
Cell Biology, Signal Transduction
Smiles
CN1C=2C (OC[C@H] (NC (=O) C3=NN (C (C) =CC3=O) C4=CC=CC=C4) C1=O) =CC=C (C#CC5CC5) C2
Molecular Formula
C27H24N4O4
Molecular Weight
468.504
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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