DALK-3
DALK-3 is a potent and selective ALK degrader, effectively eliminating EML4-ALK fusion proteins with a DC50 of 0.182 μM. It demonstrates robust anti-proliferative activity in H3122 cell-based assays, making it a valuable chemical probe for oncology research, including in vitro mechanistic studies and in vivo tumor model investigations.
Product Specifications
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
COC1=CC=C (C=C1) C (=O) /C=C/C (=O) N2CCN (CC2) C3CCN (CC3) C4=CC (=C (C=C4) NC5=NC=C (C (=N5) NC6=CC=CC=C6P (=O) (C) C) Cl) OC
Molecular Formula
C39H45ClN7O5P
Molecular Weight
758.245
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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