SAL-0010042
SAL-0010042 is a potent inhibitor of Plasmodium PDEβ (IC50=48.9 nM), blocking cAMP/cGMP hydrolysis to activate PKG and inhibit parasite growth (IC50s: 142 nM 3D7, 218 nM Dd2) . It also inhibits human PDE5 and PDE6. This compound is a valuable tool for studying cyclic nucleotide signaling in malaria parasite biology and transmission.
Product Specifications
CAS Number
521298-46-4
Field of Research
Infectious Disease & Virology, Metabolism Research
Smiles
O=C1N=C (NC=2C (=NNC12) C (C) C) CC=3C=CC=CC3F
Molecular Formula
C15H15FN4O
Molecular Weight
286.304
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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