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SAL-0010042

SAL-0010042 is a potent inhibitor of Plasmodium PDEβ (IC50=48.9 nM), blocking cAMP/cGMP hydrolysis to activate PKG and inhibit parasite growth (IC50s: 142 nM 3D7, 218 nM Dd2) . It also inhibits human PDE5 and PDE6. This compound is a valuable tool for studying cyclic nucleotide signaling in malaria parasite biology and transmission.

Product Specifications

CAS Number

521298-46-4

Field of Research

Infectious Disease & Virology, Metabolism Research

Smiles

O=C1N=C (NC=2C (=NNC12) C (C) C) CC=3C=CC=CC3F

Molecular Formula

C15H15FN4O

Molecular Weight

286.304

Storage Conditions

-20°C

Notes

For research use only.

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