IPS-06061
IPS-06061 is an orally bioavailable molecular glue degrader that recruits the E3 ligase CRBN to ubiquitinate and degrade the oncogenic mutant KRAS G12D, achieving a DC50 below 500 nM. This compound enables the study of targeted KRASG12D degradation in both cellular and animal models of cancer, supporting research in oncology and targeted protein degradation.
Product Specifications
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
CCOC (=O) [C@H] (CCC1=CC=CC=C1) C[C@@H] (C) C (=O) C2=CC=CC=C2
Molecular Formula
C22H26O3
Molecular Weight
338.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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