PROTAC JNK1-targeted-1
PA2 is a potent JNK1-targeting PROTAC degrader with a DC50 of 10 nM, effective in reducing fibronectin levels. It serves as a valuable chemical tool for investigating JNK1's role in fibrotic diseases, including in vitro and in vivo models of lung fibrosis.
Product Specifications
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
C1CC (=O) NC (=O) C1N2C (=O) C3=C (C2=O) C (=CC=C3) NCCCCNC (=O) C4=CC=C (C=C4) NC5=NC=C (C (=N5) NC6=CC=CC=C6C (=O) N) Br
Molecular Formula
C35H32BrN9O6
Molecular Weight
754.589
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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