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Keap1-IN-1

Keap1-IN-1 (Compound 27) is a covalent Keap1 inhibitor that selectively targets the Cys151 residue, disrupting the Keap1-Nrf2 interaction to activate the Nrf2/ARE pathway. It induces NQO1 expression (EC50 = 160 nM) and demonstrates cytotoxicity in U2OS cells (EC50 = 527 nM), making it a valuable chemical probe for studying oxidative stress responses in cancer and neurodegenerative disease research.

Product Specifications

Field of Research

Cancer Biology, Immunology & Inflammation, Metabolism Research

Smiles

CCP1 (=O) CCN (CC1) C2=C (N=C (S2) S (=O) (=O) CC) S (=O) (=O) C3=C (C (=CC=C3) Cl) Cl

Molecular Formula

C17H21Cl2N2O5PS3

Molecular Weight

531.434

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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