ALK/ROS1-IN-5
ALK/ROS1-IN-5 (X4) is a potent, selective dual inhibitor of ALK and ROS1 kinases, demonstrating cellular activity with an IC50 of 0.034 μM in H2228 cells. It induces dose-dependent apoptosis and suppresses p-ALK and p-ERK signaling, supporting its application in oncology research for studying ALK/ROS1-driven cancers in vitro.
Product Specifications
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
COC1=CC=C (C=C1) C2=CC (=C (C=C2) C (=O) NC3=NNC4=C3C=C (C=C4) CC5=CC (=CC (=C5) F) F) N6CCOCC6
Molecular Formula
C32H28F2N4O3
Molecular Weight
554.586
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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