CDKL5/GSK3-IN-1

CDKL5/GSK3-IN-1 (Compound 2) is a potent, selective dual inhibitor of CDKL5 and GSK3α/β, with IC50 values of 4.6 nM, 9.5 nM, and 24 nM, respectively. This chemical probe is a valuable tool for investigating the roles of these kinases in CNS disorder models, both in vitro and in vivo.