JNK3 inhibitor-9
JNK3inhibitor-9 (Compound 24a) is a brain-penetrant, selective JNK3 inhibitor (IC50=12 nM) that also potently inhibits GSK3α/β, reducing phosphorylation of Tau, c-Jun, and APP. It demonstrates neuroprotective effects against Aβ1-42 toxicity in cellular models, supporting its research application in Alzheimer's disease and related tauopathies.
Product Specifications
Field of Research
Neuroscience, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Smiles
C1C[C@H] (CN (C1) C (=O) C2CC2) NC3=NC=CC (=N3) N4C=C (C (=N4) C (=O) N) /C=C/C5=CC=CC=C5
Molecular Formula
C25H27N7O2
Molecular Weight
457.528
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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