MASP-2-IN-1
MASP-2-IN-1 (Compound 77) is a potent and selective MASP-2 inhibitor (IC50 = 11.4 nM) with weaker activity against MASP-3 and hERG. It is a research tool for studying the lectin pathway of complement activation in vitro, though it shows limited plasma stability in mice (t1/2 = 4.4 h) .
Product Specifications
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery, Protein Biochemistry
Smiles
C1=CC=C (C=C1) S (=O) (=O) NC2=CN=C (N=C2) CC (=O) NCC3=CC=C (C=C3) C4=CN=C (N4) N
Molecular Formula
C22H21N7O3S
Molecular Weight
463.512
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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