CDK4/6/HDAC-IN-1
CDK4/6/HDAC-IN-1 (N14) is a potent dual inhibitor of CDK4/6 and HDAC1/6, demonstrating low nanomolar IC50 values. It induces G0/G1 arrest and apoptosis via the HDAC-p21-CDK axis, showing efficacy in inhibiting hepatocellular carcinoma in preclinical research models.
Product Specifications
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology
Smiles
CC1=C (C (=O) N (C2=NC (=NC=C12) NC3=NC=C (C=C3) N4CCN (CC4) CC (=O) NC5=CC=C (C=C5) /C=C/C (=O) NO) C6CCCC6) C (=O) C
Molecular Formula
C35H39N9O5
Molecular Weight
665.742
Storage Conditions
-20°C
Notes
For research use only.
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