3′-Me Meayamycin D
3’-Me Meayamycin D is a potent SF3B1/PHF5A-targeting splice modulator that downregulates MCL-1. It inhibits proliferation in cancer cell lines (e.g., HCT116, A549) with GI50 values of 4.6-7.2 nM and exhibits good in vivo plasma stability (t1/2 ~16 h in mice), supporting its use in oncology and splicing mechanism research.
Product Specifications
Smiles
C[C@H]1C[C@H] ([C@H] (O[C@H]1C/C=C (\C) /C=C/[C@@H]2[C@H] ([C@@]3 (CC (O2) (C) C) CO3) O) C) NC (=O) /C=C (/C) \[C@H] (C) OCOC
Molecular Formula
C29H47NO7
Molecular Weight
521.686
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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