COX-2-IN-51

COX-2-IN-51 is a potent and selective COX-2 inhibitor (IC50 = 70.7 nM) that suppresses inflammatory mediators like PGE2 and NO by blocking the NF-κB pathway. It demonstrates significant anti-inflammatory and analgesic efficacy in murine models with an improved gastrointestinal safety profile relative to indomethacin.