COX-2-IN-51
COX-2-IN-51 is a potent and selective COX-2 inhibitor (IC50 = 70.7 nM) that suppresses inflammatory mediators like PGE2 and NO by blocking the NF-κB pathway. It demonstrates significant anti-inflammatory and analgesic efficacy in murine models with an improved gastrointestinal safety profile relative to indomethacin.
Product Specifications
CAS Number
3064260-49-4
Field of Research
Immunology & Inflammation, Neuroscience, Signal Transduction
Smiles
FC1=CC=C2OC (OCCC3=CSC=C3) (C (=CC2=C1) C=4C=CC (OC) =CC4) C (F) (F) F
Molecular Formula
C23H18F4O3S
Molecular Weight
450.446
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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