KRAS G12C inhibitor 69
KRAS G12C inhibitor 69 (Compound K09) is a potent small molecule inhibitor targeting the KRAS G12C mutant protein, demonstrating low nanomolar IC50 values in biochemical, cellular signaling (p-ERK), and proliferation assays in NCI-H358 and MIA PaCa-2 cell lines. This compound is a valuable research tool for investigating KRAS-driven oncogenesis and evaluating targeted therapies in vitro.
Product Specifications
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
C=CC (=O) N1CCN (CC1) C2=NC (=NC3=C (C (=C (C=C32) Cl) C4=C (C=CC=C4F) O) F) OC[C@@]56CCCN5C[C@@H] (C6) F
Molecular Formula
C29H29ClF3N5O3
Molecular Weight
588.02
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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