Topoisomerase IIα-IN-10
TopoisomeraseIIα-IN-10 (Compound 13r) is a catalytic inhibitor that targets the Topo IIα-DNA complex, inducing apoptosis and loss of mitochondrial membrane potential in HCT116 cells with an IC50 of 4.37 μM. It is a useful chemical probe for cancer research, particularly in studies of cell proliferation and DNA damage response mechanisms in vitro.
Product Specifications
Field of Research
Cell Biology, Metabolism Research, Molecular Biology
Smiles
CC (C) C1=CC=C (C=C1) C2=NC (=CC3=C2NC4=CC=CC=C43) CN=C (C) C5=C (C6=CC=CC=C6OC5=O) O
Molecular Formula
C32H27N3O3
Molecular Weight
501.575
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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