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PROTAC K-Ras Degrader-2

PROTAC K-Ras degrader-2 is a pan-KRAS mutant degrader with potent activity, exhibiting degradation (DC50 ≤200 nM) and growth inhibition (IC50 ≤20 nM) in KRAS-mutant cancer cell models. This tool compound is valuable for in vitro and in vivo research targeting oncogenic KRAS signaling in cancers.

Product Specifications

CAS Number

3043670-74-9

Field of Research

Pharmacology & Drug Discovery, Signal Transduction

Smiles

C (C1 (COC=2N=C (C3=C (N2) C (F) =C (N=C3) C=4C5=C (C=C (O) C4) C=CC (F) =C5CC) N6C[C@] (C) (O) CCC6) CC1) N7CCC (CN8CCN (CC8) C9=CC (F) =C (C (F) =C9) C%10C (=O) NC (=O) CC%10) (C) CC7

Molecular Formula

C52H60F4N8O5

Molecular Weight

953.077

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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