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XY221

Compound 16o (XY221) is a potent and highly selective BRD4 BD2 inhibitor (IC50 = 5.8 nM), showing >600-fold selectivity over BRD4 BD1. It induces apoptosis in MV4-11 leukemia cells and exhibits anti-cancer activity in cellular assays, supporting its use in oncology and epigenetics research.

Product Specifications

Field of Research

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Smiles

CCC1=NC (=C (N1) COC) C2=CC3=C (O2) C (=CN (C3=O) C) C4=C (C=CC (=C4) C (C) (C) O) OC5=C (C=C (C=C5C) F) C

Molecular Formula

C32H34FN3O5

Molecular Weight

559.628

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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