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H122

H122 is a potent TEAD-targeting PROTAC degrader with low nanomolar activity against TEAD1-4. It downregulates Myc expression, inhibits mesothelioma cell growth in vitro, and demonstrates antitumor efficacy in mouse models, supporting research in Hippo pathway and cancer therapeutics.

Product Specifications

Field of Research

Cell Biology, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Smiles

COCCOC1=C (C (=C (C=C1) C (=O) N) C2=C (C=CC3=C2C[C@@] (O3) (CNCCC4CCN (CC4) C5=CC6=C (C=C5) C (=O) N (C6=O) C7CCC (=O) NC7=O) C8=CC=CC=C8) Cl) F

Molecular Formula

C45H45ClFN5O8

Molecular Weight

838.319

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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