H122
H122 is a potent TEAD-targeting PROTAC degrader with low nanomolar activity against TEAD1-4. It downregulates Myc expression, inhibits mesothelioma cell growth in vitro, and demonstrates antitumor efficacy in mouse models, supporting research in Hippo pathway and cancer therapeutics.
Product Specifications
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Smiles
COCCOC1=C (C (=C (C=C1) C (=O) N) C2=C (C=CC3=C2C[C@@] (O3) (CNCCC4CCN (CC4) C5=CC6=C (C=C5) C (=O) N (C6=O) C7CCC (=O) NC7=O) C8=CC=CC=C8) Cl) F
Molecular Formula
C45H45ClFN5O8
Molecular Weight
838.319
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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