Molibresib

Molibresib (I-BET762; GSK525762) is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.

Product Specifications

CAS Number

[1260907-17-2]

Product Name Alternative

I-BET762; GSK525762; GSK525762A

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GSK-525762A.html

Purity

99.94

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(C2=N[C@@H](CC(NCC)=O)C3=NN=C(C)N3C4=CC=C(OC)C=C24)C=C1

Molecular Formula

C22H22ClN5O2

Molecular Weight

423.90

Precautions

H302, H315, H319, H335

References & Citations

[1]Nicodeme E, et al. Suppression of inflammation by a synthetic histone mimic. Nature. 2010 Dec 23;468 (7327) :1119-23.|[2]Asangani IA, et al. Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer. Nature. 2014 Jun 12;510 (7504) :278-82.|[3]Chaidos A, et al. Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762. Blood. 2014 Jan 30;123 (5) :697-705.