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DS79932728

DS79932728 is a potent, orally bioavailable dual inhibitor of G9a and GLP (IC50s: 12.6 nM and 75.7 nM, respectively) . It elevates fetal hemoglobin (HbF) by inducing γ-globin expression, as demonstrated by increased F-reticulocytes in cynomolgus monkey studies, supporting its research for hemoglobinopathies like sickle cell disease.

Product Specifications

CAS Number

2757191-62-9

Field of Research

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Smiles

N=1C2=CC (=C (OC) C=C2C3 (C1N) CCC3) C4=CCN (C) CCC4

Molecular Formula

C19H25N3O

Molecular Weight

311.421

Storage Conditions

-20°C

Notes

For research use only.

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