DS79932728
DS79932728 is a potent, orally bioavailable dual inhibitor of G9a and GLP (IC50s: 12.6 nM and 75.7 nM, respectively) . It elevates fetal hemoglobin (HbF) by inducing γ-globin expression, as demonstrated by increased F-reticulocytes in cynomolgus monkey studies, supporting its research for hemoglobinopathies like sickle cell disease.
Product Specifications
CAS Number
2757191-62-9
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
N=1C2=CC (=C (OC) C=C2C3 (C1N) CCC3) C4=CCN (C) CCC4
Molecular Formula
C19H25N3O
Molecular Weight
311.421
Storage Conditions
-20°C
Notes
For research use only.
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