Recombinant Rat IL-2 Protein (GST Tag)
Product Specifications
Background
IL-2 (Interleukin 2) is a critical cytokine in T cell biology. It promotes T cell activation and expansion, the development, maintenance and function of regulatory T cells (Treg), and the differentiation of CD8+ T cells into terminal effector cells and memory cells. IL-2 signals through a receptor complex composed of CD25/IL-2 R alpha, IL-2 R beta, and the Common gamma Chain (gamma c) . IL-2 R beta is also a component of the IL-15 receptor complex. Gamma c is also a signaling subunit in the receptors for IL-4, -7, -9, -15, and -21.
Abbreviation
IL-2
Synonyms
POIL; Aldesleukin; Interleukin-2; Involved in regulation of T cell clonal expansion; POIL2; T-cell growth factor; IL 2; IL2; lymphokine; TCGF; interleukin 2; T cell growth factor; Il-2
UniProt
P17108
Accession Number
P17108
Expression System
E.coli
Tag
N-GST
Sequence
Ala21-Gln155
Field of Research
Cancer; Immunology; Cell Biology; Signal Transduction
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
40.8 kDa
Observed Molecular Weight
42 kDa
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Species
Rat
Available Sizes
Curated Selection
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