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Pyrimidinone 8

Pyrimidinone 8 is a reversible, linear non-competitive inhibitor of human DMT1 (Ki=20 μM) that blocks cellular iron uptake (IC50=13.8 μM) without altering transporter surface expression or pH sensitivity. This tool compound is useful for in vitro studies of iron metabolism and metal transporter biology.

Product Specifications

CAS Number

65004-42-4

Field of Research

Pharmacology & Drug Discovery

Smiles

O=C1N=C (NC (=C1) C) N2N=C (C=C2C) C

Molecular Formula

C10H12N4O

Molecular Weight

204.229

Storage Conditions

-20°C

Notes

For research use only.

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