DP-15
DP-15 is a potent bifunctional degrader of GSPT1 and BRD4, demonstrating nanomolar-range DC50 values. It exhibits strong antiproliferative effects, induces G1 arrest and apoptosis in AML cells like MOLM13, and shows in vivo efficacy in xenograft models, supporting its use in oncology research for leukemia and lymphoma studies.
Product Specifications
CAS Number
3033837-71-4
Field of Research
Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
CC=1C2=C (N3C ([C@H] (CC (=O) N4CCN (CC5CCN (CC5) C=6C=C7C (=CC6) C (=O) N (C7=O) C8C (=O) NC (=O) CC8) CC4) N=C2C9=CC=C (Cl) C=C9) =NN=C3C) SC1C
Molecular Formula
C42H44ClN9O5S
Molecular Weight
822.374
Storage Conditions
-20°C
Notes
For research use only.
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