KRAS inhibitor-27
KRAS inhibitor-27 (Compound 15h) is a potent small molecule targeting KRAS G12D/G12V mutations and wild-type KRAS, inhibiting MAPK signaling via ERK phosphorylation and DUSP4 reduction. It is a valuable tool for in vitro cancer research, particularly in studying pancreatic and colorectal cancer cell models like AsPC-1, SW620, and HT-29.
Product Specifications
CAS Number
3033690-83-1
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
N#CC1=C (SC2=C (F) C=CC (C=3C (F) =C4N=C (N=C5C4=C (OCC6N5CCCOC6) C3Cl) OCC78N (CCC7) CC (F) C8) =C12) N
Molecular Formula
C31H28ClF3N6O3S
Molecular Weight
657.106
Storage Conditions
-20°C
Notes
For research use only.
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