PIKfyve-IN-4

PIKfyve-IN-4 (Compound 40) is a potent, selective, and orally bioavailable inhibitor of PIKfyve kinase, exhibiting an IC50 of 0.60 nM. It is a valuable research tool for investigating lysosomal function and autophagy in cellular models and has demonstrated systemic tolerability in vivo for preclinical studies.