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PD-L1/HDAC-IN-1

PD-L1/HDAC-IN-1 (Compound 14) is a dual inhibitor of the PD-1/PD-L1 axis and HDAC2/3, with IC50 values in the nanomolar range. It upregulates PD-L1 and CXCL10 in vitro, promoting T-cell recruitment to the tumor microenvironment for immune-oncology research in both cellular and animal models.

Product Specifications

CAS Number

2923313-69-1

Field of Research

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Immunology & Inflammation; Epigenetics & Chromatin, Molecular Biology

Smiles

C (C1=C (OCC2=CC (C#N) =CC=C2) C=C (OCC3=C (C) C (=CC=C3) C4=CC (OCCCCCCC (NO) =O) =CC=C4) C (Cl) =C1) N5[C@@H] (C (O) =O) CCCC5

Molecular Formula

C42H46ClN3O7

Molecular Weight

740.284

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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